Immunosuppressive cyclolignans

被引：76

作者：

Gordaliza, M ^{[1
]}

Faircloth, GT ^{[1
]}

Castro, MA ^{[1
]}

delCorral, JMM ^{[1
]}

LopezVazquez, ML ^{[1
]}

SanFeliciano, A ^{[1
]}

机构：

[1] PHARMAMAR USA INC, CAMBRIDGE, MA 02139 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 14期

关键词：

D O I：

10.1021/jm960023h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.

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页码：2865 / 2868

页数：4

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