SYNTHESIS AND EVALUATION OF PYRAZOLIGNANS - A NEW CLASS OF CYTOTOXIC AGENTS

被引：32

作者：

GORDALIZA, M

DELCORRAL, JMM

CASTRO, MA

LOPEZVAZQUEZ, ML

FELICIANO, AS

GARCIAGRAVALOS, MD

CARPY, A

机构：

[1] UNIV SALAMANCA, FAC FARM, QUIM FARMACEUT LAB, E-37007 SALAMANCA, SPAIN

[2] PHARMAMAR SA, E-28070 MADRID, SPAIN

[3] UNIV BORDEAUX 2, CHIM ANALYT LAB, F-33076 BORDEAUX, FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 09期

关键词：

D O I：

10.1016/0968-0896(95)00091-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC50 values at mu M levels.

引用

页码：1203 / 1210

页数：8

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