Whole tissue AC susceptibility after superparamagnetic iron oxide contrast agent administration in a rat model

被引：7

作者：

Lazaro, Francisco Jose

Gutierrez, Lucia

Abadia, Ana Rosa

Romero, Maria Soledad

Lopez, Antonio

Munoz, Maria Jesus

机构：

[1] Univ Zaragoza, Ctr Politecn Super, Dept Ciencia & Tecnol Mat & Fluidos, Zaragoza 50018, Spain

[2] Univ Zaragoza, Inst Nanociencia Aragon, E-50009 Zaragoza, Spain

[3] Univ Zaragoza, Dept Fisiol & Farmacol, E-50013 Zaragoza, Spain

[4] Univ Zaragoza, Dept Med & Psiquiatria, E-50009 Zaragoza, Spain

[5] CNAM Zaragoza, Zaragoza 50009, Spain

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

AC susceptibility; superparamagnetism; MRI contrast agent; rat model; ferritin; MAGNETIC CHARACTERIZATION;

D O I：

10.1016/j.jmmm.2006.10.1168

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A magnetic AC susceptibility characterisation of rat tissues after intravenous administration of superparamagnetic iron oxide (Endorem(R)), at the same dose as established for Magnetic Resonance Imaging (MRI) contrast enhancement in humans, has been carried out. The measurements reveal the presence of the contrast agent as well as that of physiological ferritin in liver and spleen while no traces have been magnetically detected in heart and kidney. This preliminary work opens suggestive possibilities for future biodistribution studies of any type of magnetic carriers. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：460 / 463

页数：4

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