miRNAs as molecular biomarkers of cancer

被引：72

作者：

Fabbri, Muller ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2010年 / 10卷 / 04期

关键词：

biomarkers; cancer; miRNAs; oncogene; tumor-suppressor gene; CHRONIC LYMPHOCYTIC-LEUKEMIA; ESTROGEN-RECEPTOR-ALPHA; ACUTE MYELOID-LEUKEMIA; HUMAN BREAST-CANCER; MICRORNA EXPRESSION PATTERNS; CELL-PROLIFERATION; DOWN-REGULATION; LUNG-CANCER; DERIVATIVE CHROMOSOME-9; PROGNOSTIC IMPLICATIONS;

D O I：

10.1586/ERM.10.27

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

miRNAs are noncoding RNAs that regulate gene expression. The advent of high-throughput techniques has revealed that miRNA expression is deregulated in almost all human tumors (both solid and hematologic) with respect to the normal tissue counterpart. These differences frequently recur in tumor-specific miRNA signatures, which are very helpful to diagnose the tissue of origin of the neoplasia, and sometimes also specific tumor subtypes. Increasing evidence also supports a role for miRNAs as prognostic biomarkers of human cancers. Finally, miRNAs are differentially expressed in the blood of cancer patients versus healthy donors, providing a rationale for the detection of miRNAs and diagnostic and prognostic circulating biomarkers.

引用

页码：435 / 444

页数：10

共 125 条

[61] MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma [J].

Lawrie, Charles H. ;

Soneji, Shamit ;

Marafioti, Teresa ;

Cooper, Christopher D. O. ;

Palazzo, Stefano ;

Paterson, Jennifer C. ;

Cattan, Helen ;

Enver, Tariq ;

Mager, Rachel ;

Boultwood, Jacqueline ;

Wainscoat, James S. ;

Hatton, Christian S. R. .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (05) :1156-1161

[62] MicroRNA genes are transcribed by RNA polymerase II [J].

Lee, Y ;

Kim, M ;

Han, JJ ;

Yeom, KH ;

Lee, S ;

Baek, SH ;

Kim, VN .

EMBO JOURNAL, 2004, 23 (20) :4051-4060

[63] Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells [J].

Li, Jinghuan ;

Smyth, Paul ;

Flavin, Richard ;

Cahill, Susanne ;

Denning, Karen ;

Aherne, Sinead ;

Guenther, Simone M. ;

O'Leary, John J. ;

Sheils, Orla .

BMC BIOTECHNOLOGY, 2007, 7 (1)

[64] Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma [J].

Li, Wenxi ;

Xie, Lu ;

He, Xianghuo ;

Li, Jinjun ;

Tu, Kang ;

Wei, Lin ;

Wu, Jun ;

Guo, Yong ;

Ma, Xi ;

Zhang, Pingping ;

Pan, Zhimei ;

Hu, Xin ;

Zhao, Yingjun ;

Xie, Haiyang ;

Jiang, Guoping ;

Chen, Taoyang ;

Wang, Jianneng ;

Zheng, Shusen ;

Cheng, Jing ;

Wan, Dafang ;

Yang, Shengli ;

Li, Yixue ;

Gu, Jianren .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (07) :1616-1622

[65] An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues [J].

Liu, CG ;

Calin, GA ;

Meloon, B ;

Gamliel, N ;

Sevignani, C ;

Ferracin, M ;

Dumitru, CD ;

Shimizu, M ;

Zupo, S ;

Dono, M ;

Alder, H ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9740-9744

[66] ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance [J].

Louie, MC ;

Zou, JX ;

Rabinovich, A ;

Chen, HW .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (12) :5157-5171

[67] MicroRNA expression profiles classify human cancers [J].

Lu, J ;

Getz, G ;

Miska, EA ;

Alvarez-Saavedra, E ;

Lamb, J ;

Peck, D ;

Sweet-Cordero, A ;

Ebet, BL ;

Mak, RH ;

Ferrando, AA ;

Downing, JR ;

Jacks, T ;

Horvitz, HR ;

Golub, TR .

NATURE, 2005, 435 (7043) :834-838

[68] Tumour invasion and metastasis initiated by microRNA 10b in breast cancer [J].

Ma, Li ;

Teruya-Feldstein, Julie ;

Weinberg, Robert A. .

NATURE, 2007, 449 (7163) :682-U2

[69] MicroRNA expression in cytogenetically normal acute myeloid leukemia [J].

Marcucci, Guido ;

Radmacher, Michael D. ;

Maharry, Kati ;

Mrozek, Krzysztof ;

Ruppert, Amy S. ;

Paschka, Peter ;

Vukosavljevic, Tamara ;

Whitman, Susan P. ;

Baldus, Claudia D. ;

Langer, Christian ;

Liu, Chang-Gong ;

Carroll, Andrew J. ;

Powell, Bayard L. ;

Garzon, Ramiro ;

Croce, Carlo M. ;

Kolitz, Jonathan E. ;

Caligiuri, Michael A. ;

Larson, Richard A. ;

Bloomfield, Clara D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (18) :1919-1928

[70] Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis [J].

Marton, S. ;

Garcia, M. R. ;

Robello, C. ;

Persson, H. ;

Trajtenberg, F. ;

Pritsch, O. ;

Rovira, C. ;

Naya, H. ;

Dighiero, G. ;

Cayota, A. .

LEUKEMIA, 2008, 22 (02) :330-338

← 2 3 4 5 6 7 8 9 10 11 →