Emergence and evolution of Vibrio cholerae O139

被引:123
作者
Faruque, SM
Sack, DA
Sack, RB
Colwell, RR
Takeda, Y
Nair, GB
机构
[1] Int Ctr Diarrhoeal Dis Res, Div Sci Lab, Dhaka 1212, Bangladesh
[2] Johns Hopkins Univ, Dept Int Hlth, Baltimore, MD 21205 USA
[3] Univ Maryland, Inst Biotechnol, Ctr Marine Biotechnol, Baltimore, MD 21202 USA
[4] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
[5] Jissen Womens Univ, Fac Human Life Sci, Tokyo 1918510, Japan
关键词
D O I
10.1073/pnas.0337468100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The emergence of Vibrio cholerae O139 Bengal during 1992-1993 was associated with large epidemics of cholera in India and Bangladesh and, initially, with a total displacement of the existing V. cholerae O1 strains. However, the O1 strains reemerged in 1994 and initiated a series of disappearance and reemergence of either of the two sero-groups that was associated with temporal genetic and phenotypic changes sustained by the strains. Since the initial emergence of the O139 vibrios, new variants of the pathogen derived from multiple progenitors have been isolated and characterized. The clinical and epidemiological characteristics of these strains have been studied. Rapid genetic reassortment in O139 strains appears to be a response to the changing epidemiology of V. cholerae O1 and also a strategy for persistence in competition with strains of the O1 serogroup. The emergence of V. cholerae O139 has provided a unique opportunity to witness genetic changes in V. cholerae that may be associated with displacement of an existing serogroup by a newly emerging one and, thus, provide new insights into the epidemiology of cholera. The genetic changes and natural selection involving both environmental and host factors are likely to influence profoundly the genetics, epidemiology, and evolution of toxigenic V. cholerae, not only in the Ganges Delta region of India and Bangladesh, but also in other areas of endemic and epidemic cholera.
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页码:1304 / 1309
页数:6
相关论文
共 59 条
  • [1] ALBERT MJ, 1993, LANCET, V342, P387, DOI 10.1016/0140-6736(93)92811-7
  • [2] BAKER A, 1994, J BACTERIOL, V176, P5450
  • [3] Heterogeneity in the organization of the CTX genetic element in strains of Vibrio cholerae O139 Bengal isolated from Calcutta, India and Dhaka, Bangladesh and its possible link to the dissimilar incidence of O139 cholera in the two locales
    Basu, A
    Mukhopadhyay, AK
    Sharma, C
    Jyot, J
    Gupta, N
    Ghosh, A
    Bhattacharya, SK
    Takeda, Y
    Faruque, ASG
    Albert, MJ
    Nair, GB
    [J]. MICROBIAL PATHOGENESIS, 1998, 24 (03) : 175 - 183
  • [4] Vibrio cholerae O139 in Calcutta, 1992-1998:: Incidence, antibiograms, and genotypes
    Basu, A
    Garg, P
    Datta, S
    Chakraborty, S
    Bhattacharya, T
    Khan, A
    Ramamurthy, T
    Bhattacharya, SK
    Yamasaki, S
    Takeda, Y
    Nair, GB
    [J]. EMERGING INFECTIOUS DISEASES, 2000, 6 (02) : 139 - 147
  • [5] Beltrán P, 1999, J CLIN MICROBIOL, V37, P581
  • [6] THE NOVEL EPIDEMIC STRAIN O139 IS CLOSELY-RELATED TO THE PANDEMIC STRAIN O1 OF VIBRIO-CHOLERAE
    BERCHE, P
    POYART, C
    ABACHIN, E
    LELIEVRE, H
    VANDEPITTE, J
    DODIN, A
    FOURNIER, JM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (03) : 701 - 704
  • [7] CLINICAL PROFILE OF ACUTE DIARRHEA CASES INFECTED WITH THE NEW EPIDEMIC STRAIN OF VIBRIO-CHOLERAE O139 - DESIGNATION OF THE DISEASE AS CHOLERA
    BHATTACHARYA, SK
    BHATTACHARYA, MK
    NAIR, GB
    DUTTA, D
    DEB, A
    RAMAMURTHY, T
    GARG, S
    SAHA, PK
    DUTTA, P
    MOITRA, A
    MANDAL, BK
    SHIMADA, T
    TAKEDA, Y
    DEB, BC
    [J]. JOURNAL OF INFECTION, 1993, 27 (01) : 11 - 15
  • [8] GENESIS OF THE NOVEL EPIDEMIC VIBRIO-CHOLERAE-0139 STRAIN - EVIDENCE FOR HORIZONTAL TRANSFER OF GENES INVOLVED IN POLYSACCHARIDE SYNTHESIS
    BIK, EM
    BUNSCHOTEN, AE
    GOUW, RD
    MOOI, FR
    [J]. EMBO JOURNAL, 1995, 14 (02) : 209 - 216
  • [9] Genetic organization and functional analysis of the otn DNA essential for cell-wall polysaccharide synthesis in Vibrio cholerae O139
    Bik, EM
    Bunschoten, AE
    Willems, RJL
    Chang, ACY
    Mooi, FR
    [J]. MOLECULAR MICROBIOLOGY, 1996, 20 (04) : 799 - 811
  • [10] COMPARISON OF VIBRIO-CHOLERAE O139 WITH VIBRIO-CHOLERAE O1 CLASSICAL AND EL-TOR BIOTYPES
    CALIA, KE
    MURTAGH, M
    FERRARO, MJ
    CALDERWOOD, SB
    [J]. INFECTION AND IMMUNITY, 1994, 62 (04) : 1504 - 1506