Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora .1. Taxonomy, fermentation, isolation, and biological activities

被引：165

作者：

Romero, F ^{[1
]}

Espliego, F ^{[1
]}

Baz, JP ^{[1
]}

DeQuesada, TG ^{[1
]}

Gravalos, D ^{[1
]}

DelaCalle, F ^{[1
]}

FernadezPuertes, JL ^{[1
]}

机构：

[1] PHARMAMAR SA,DRUG DISCOVERY DIV,LEON 24196,SPAIN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 09期

关键词：

D O I：

10.7164/antibiotics.50.734

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.

引用

页码：734 / 737

页数：4

共 12 条

[1] INHIBITION OF DIHYDROFOLATE-REDUCTASE - EFFECT OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE ON THE SELECTIVITY AND AFFINITY OF DIAMINOBENZYLPYRIMIDINES [J].