Successful Treatment of Balamuthia mandrillaris Amoebic Infection with Extensive Neurological and Cutaneous Involvement

被引:70
作者
Martinez, Dalila Y. [1 ]
Seas, Carlos [1 ,2 ]
Bravo, Francisco [1 ,2 ]
Legua, Pedro [1 ,2 ]
Ramos, Cesar [2 ]
Cabello, Alfonso M. [1 ]
Gotuzzo, Eduardo [1 ,2 ]
机构
[1] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander von Humboldt, Lima 31, Peru
[2] Hosp Nacl Cayetano Heredia, Dept Enfermedades Infecciosas Trop & Dermatol, Lima, Peru
关键词
MENINGOENCEPHALITIS; ENCEPHALITIS; ACANTHAMOEBA; MILTEFOSINE; ANIMALS; HUMANS; AGENT;
D O I
10.1086/653609
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris is an uncommon infection for which there is no optimal therapy. We describe a young, female patient who presented with extensive cutaneous and neurological involvement and who recovered after receiving prolonged treatment with miltefosine, fluconazole, and albendazole.
引用
收藏
页码:E7 / E11
页数:5
相关论文
共 13 条
[1]   Identification of Balamuthia mandrillaris by PCR assay using the mitochondrial 16S rRNA gene as a target [J].
Booton, GC ;
Carmichael, JR ;
Visvesvara, GS ;
Byers, TJ ;
Fuerst, PA .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (01) :453-455
[2]  
Bravo FG, 2005, Tropical Dermatology, P49
[3]   Successful treatment of Balamuthia amoebic encephalitis:: Presentation of 2 cases [J].
Deetz, TR ;
Sawyer, MH ;
Billman, G ;
Schuster, FL ;
Visvesvara, GS .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (10) :1304-1312
[4]  
Glaser C., 2008, Morbidity and Mortality Weekly Report, V57, P768
[5]  
Jung SM, 2004, ARCH PATHOL LAB MED, V128, P466
[6]   Increasing importance of Balamuthia mandrillaris [J].
Matin, Abdul ;
Siddiqui, Ruqaiyyah ;
Jayasekera, Samantha ;
Khan, Naveed Ahmed .
CLINICAL MICROBIOLOGY REVIEWS, 2008, 21 (03) :435-448
[7]   Axenic growth and drug sensitivity studies of Balamuthia mandrillaris, an agent of amebic meningoencephalitis in humans and other animals [J].
Schuster, FL ;
Visvesvara, GS .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (02) :385-388
[8]   In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas:: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri [J].
Schuster, FL ;
Guglielmo, BJ ;
Visvesvara, GS .
JOURNAL OF EUKARYOTIC MICROBIOLOGY, 2006, 53 (02) :121-126
[9]  
Seas R Carlos, 2006, Rev. chil. infectol., V23, P197
[10]   Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity [J].
Siddiqui, Ruqaiyyah ;
Matin, Abdul ;
Warhurst, David ;
Stins, Monique ;
Khan, Naveed Ahmed .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (12) :4471-4473