Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra)

被引：50

作者：

dos Santos, MD

Gobbo-Neto, L

Albarella, L

de Souza, GEP

Lopes, NP

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Salerno, Fac Farm, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Lychnophora ericoides; Asteraceae; analgesic; roots; di-caffeoylquinic acids;

D O I：

10.1016/j.jep.2004.09.043

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The Brazilian medicinal plant Lychnophora ericoides Mart. (Asteraceae) has been used in traditional medicine to treat wounds, pain and inflammation. As part of our continuing investigation of this commercial phytomedicine, we focused on the polar fractions of the plant, since it is employed as alcoholic and hydroalcoholic preparations. The analgesic bioguided fractionation of the root polar extract yielded 3,5-di-O-[E]-caffeoylquinic acid, 4,5-di-O-[E]-caffcoylquinic acid and 3,4,5-tri-O-[E]-caffeoylquinic acid. The n-butanol fraction and the di-caffeoylquinic acids showed significant analgesic activity in the acetic acid-induced mouse writhing test at low but not at high doses. These findings support, at least in part, the validity of the use of Lychnophora ericoides roots in traditional medicine. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：545 / 549

页数：5

共 27 条

[11] The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65 [J].