The synthesis of allyl- and allyloxycarbonyl-protected RNA posphoramidites. Useful reagents for solid-phase synthesis of RNAs with base-labile modifications.

被引：17

作者：

Bogdan, FM ^{[1
]}

Chow, CS ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 14期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)00157-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of allyl-and allyloxycarbonyl (AOC)-protected RNA phosphoramidites is reported. The use of allyl and AOC groups allows the chemistry of solid-phase RNA synthesis to be expanded to include base-labile modified nucleosides, such as acetylcytidine. The allyl-and AOC-protective chemistry can be further expanded for the construction of RNAs on solid supports and affinity columns. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1897 / 1900

页数：4

共 15 条

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