Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity

被引：66

作者：

Dutertre, Sebastien ^{[1
]}

Biass, Daniel ^{[1
]}

Stoecklin, Reto ^{[1
]}

Favreau, Philippe ^{[1
]}

机构：

[1] Atheris Labs, CH-1233 Bernex Geneva, Switzerland

来源：

TOXICON | 2010年 / 55卷 / 08期

关键词：

Venom; Conopeptide; Conus consors; Mass spectrometry; Intraspecimen variation; NICOTINIC ACETYLCHOLINE-RECEPTOR; MASS-SPECTROMETRY; INTERSEXUAL VARIATIONS; SPIDER VENOM; CONOTOXIN; PEPTIDES; SNAILS; IDENTIFICATION; COMPLEXITY; MECHANISM;

D O I：

10.1016/j.toxicon.2010.02.025

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the advent of highly sensitive mass spectrometry techniques, the minute amount of various secretions produced by living animals can be studied to a level of details never attained before. In this study, we used LC-ESI-MS to analyse the injected venom of an indo-pacific piscivorous cone snail, Conus consors. While long-term follow up of several captive specimens have revealed a typical "venom fingerprint" for this species, dramatic variations were also observed. In the most extreme case, a single cone snail unexpectedly produced two very distinct venom profiles containing completely different sets of peptides with no overlap of detected masses. Surprisingly, there was no correlation between the peptides produced in the venom duct and those obtained after milking live cone snails, implying yet unknown mechanisms of selection and regulation. Our study defines the notion of intra-specimen variation and demonstrates how this phenomenon contributes to the overall venom diversity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1453 / 1462

页数：10

共 40 条

[21] One scorpion, two venoms:: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action [J].