ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490I.: Taxonomy, fermentation, isolation and biological activities

被引：4

作者：

Inoue, H

Kumagai, H

Osono, M

Matsufuji, M

Sameshima, T

Kawamura, N

Someno, T

Ishizuka, M

Takeuchi, T

机构：

[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan

[2] Mercian Co Ltd, Bioresource Res Labs, Fujisawa, Kanagawa 2510057, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期

关键词：

D O I：

10.7164/antibiotics.56.209

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 mug/ml and showed weak cytotoxicity against bone marrow cells.

引用

页码：209 / 213

页数：5