LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become

被引：186

作者：

Constantine-Paton, M

Cline, HT

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(98)80017-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent data suggest that long-term potentiation and activity-dependent synaptogenesis share the same mechanism at the initiation stage during which NMDA receptor activity is necessary to increase the postsynaptic response via AMPA receptor currents. However, several fundamental differences between the environments of young and mature synapses and the neurons that support them suggest that the same cellular mechanism is facilitated by very different parameters in the young versus the mature brain.

引用

页码：139 / 148

页数：10

共 67 条

[21] Flint AC, 1997, J NEUROSCI, V17, P2469
[22] Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex
Fox, K
Schlaggar, BL
Glazewski, S
OLeary, DDM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) : 5584 - 5589
[23] THE CRITICAL PERIOD FOR LONG-TERM POTENTIATION IN PRIMARY SENSORY CORTEX
FOX, K
[J]. NEURON, 1995, 15 (03) : 485 - 488
[24] Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice
Gordon, JA
Cioffi, D
Silva, AJ
Stryker, MP
[J]. NEURON, 1996, 17 (03) : 491 - 499
[25] Activity-dependent wiring of the developing hippocampal neuronal circuit
Hanse, E
Durand, GM
Garaschuk, O
Konnerth, A
[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1997, 8 (01) : 35 - 42
[26] LEARNING TO MODULATE TRANSMITTER RELEASE - THEMES AND VARIATIONS IN SYNAPTIC PLASTICITY
HAWKINS, RD
KANDEL, ER
SIEGELBAUM, SA
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1993, 16 : 625 - 665
[27] Experimental down-regulation of the NMDA channel associated with synapse pruning
Hickmott, PW
ConstantinePaton, M
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1997, 78 (02) : 1096 - 1107
[28] EVIDENCE FOR SILENT SYNAPSES - IMPLICATIONS FOR THE EXPRESSION OF LTP
ISAAC, JTR
NICOLL, RA
MALENKA, RC
[J]. NEURON, 1995, 15 (02) : 427 - 434
[29] ISAAC JTR, 1997, NEURON, V181, P1
[30] STRUCTURE AND FUNCTION OF THE BRAIN-SEROTONIN SYSTEM
JACOBS, BL
AZMITIA, EC
[J]. PHYSIOLOGICAL REVIEWS, 1992, 72 (01) : 165 - 229

← 1 2 3 4 5 6 7 →