Lamin-binding Proteins

被引：192

作者：

Wilson, Katherine L. ^{[2
]}

Foisner, Roland ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Med Biochem, Max F Perutz Labs, A-1030 Vienna, Austria

[2] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NUCLEAR-MEMBRANE PROTEIN; A-TYPE LAMINS; TO-AUTOINTEGRATION FACTOR; DISTINCT FUNCTIONAL DOMAINS; ENVELOPE INNER MEMBRANE; B-RECEPTOR; LEM-DOMAIN; MUSCULAR-DYSTROPHY; KASH-DOMAIN; TRANSCRIPTIONAL REPRESSOR;

D O I：

10.1101/cshperspect.a000554

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A- and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in a plethora of stable and transient interactions, near the inner nuclear membrane and throughout the nucleus. Lamin-binding proteins serve an amazingly diverse range of functions. Numerous inner-membrane proteins help anchor lamin filaments to the nuclear envelope, serving as part of the nuclear "lamina" network that is essential for nuclear architecture and integrity. Certain lamin-binding proteins of the inner membrane bind partners in the outer membrane and mechanically link lamins to the cytoskeleton. Inside the nucleus, lamin-binding proteins appear to serve as the "adaptors" by which the lamina organizes chromatin, influences gene expression and epigenetic regulation, and modulates signaling pathways. Transient interactions of lamins with key components of the transcription and replication machinery may provide an additional level of regulation or support to these essential events.

引用

页数：17

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