The jerangolids: A family of new antifungal compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties of jerangolid A

被引：73

作者：

Gerth, K ^{[1
]}

Washausen, P ^{[1
]}

Hofle, G ^{[1
]}

Irschik, H ^{[1
]}

Reichenbach, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,ABT NATURSTOFFCHEM,D-38124 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期

关键词：

D O I：

10.7164/antibiotics.49.71

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The activity was excreted into the supernatant during the log and early stationary phase. When the organism was fermented in the presence of the adsorber resin XAD-16, the metabolite was quantitatively bound to the resin. The main component, jerangolid A, has structural similarities to ambruticin, which is also produced by strains of Sorangium cellulosum.

引用

页码：71 / 75

页数：5

共 6 条

[1]

ARIMA K, 1964, AGR BIOL CHEM TOKYO, V28, P474

[2] PYRROLNITRIN FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES) [J].

GERTH, K ;

TROWITZSCH, W ;

WRAY, V ;

HOFLE, G ;

IRSCHIK, H ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1982, 35 (08) :1101-1103

[3] THE SORAPHENS - A FAMILY OF NOVEL ANTIFUNGAL COMPOUNDS FROM SORANGIUM-CELLULOSUM (MYXOBACTERIA) .1. SORAPHEN A(1-ALPHA) - FERMENTATION, ISOLATION, BIOLOGICAL PROPERTIES [J].

GERTH, K ;

BEDORF, N ;

IRSCHIK, H ;

HOFLE, G ;

REICHENBACH, H .

JOURNAL OF ANTIBIOTICS, 1994, 47 (01) :23-31

[4]

HOFLE G, 1991, LIEBIGS ANN CHEM, P941, DOI 10.1002/jlac.1991199101161

[5] AMBRUTICIN (W7783), A NEW ANTIFUNGAL ANTIBIOTIC [J].

RINGEL, SM ;

GREENOUGH, RC ;

ROEMER, S ;

CONNOR, D ;

GUTT, AL ;

BLAIR, B ;

KANTER, G ;

STRANDTMANN, MV .

JOURNAL OF ANTIBIOTICS, 1977, 30 (05) :371-375

[6]

WASHAUSEN P, UNPUB LIEBIGS ANN CH

← 1 →