Asymmetric synthesis of (+)-negamycin

被引：69

作者：

Davies, SG

Ichihara, O

机构：

[1] Dyson Perrins Laboratory, University of Oxford, Oxford OX1 3QY, South Parks Road

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 07期

关键词：

D O I：

10.1016/0957-4166(96)00230-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(+)-Negamycin was synthesised employing the highly diastereoselective conjugate addition of lithium (alpha-methylbenzyl)benzylamide in the key step. The synthesis was completed in 13 steps starting from ethyl 4-chloroacetoacetate with an overall yield of 24 %. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1919 / 1922

页数：4

共 18 条

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