Cytomegalovirus infection and schizencephaly: Case reports

被引：77

作者：

Iannetti, P

Nigro, G

Spalice, A

Faiella, A

Boncinelli, E

机构：

[1] Univ Roma La Sapienza, Dept Pediat, Child Neurol Div, I-00161 Rome, Italy

[2] HS Raffaele, Dibit Sci Inst, Milan, Italy

来源：

ANNALS OF NEUROLOGY | 1998年 / 43卷 / 01期

关键词：

D O I：

10.1002/ana.410430122

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two children with left open-lip schizencephaly are reported. Cytomegalovirus (CMV) infection was demonstrated on the second day of life in Patient 1; in the other patient CMV infection was observed at the age of 4 years. Magnetic resonance imaging revealed polymicrogyria cortex lining the clefts. In Patient 2 polymicrogyria was also present in the corresponding area contralateral to the schizencephaly. Computed tomography revealed the presence of subependymal periventricular calcifications. Genetic analysis did not demonstrate the presence of EMX2 homeobox gene. The possible role of CMV infection in the complex multifactorial pathogenesis of schizencephaly is therefore suggested.

引用

页码：123 / 127

页数：5

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