The Subventricular Zone Is the Developmental Milestone of a 6-Layered Neocortex: Comparisons in Metatherian and Eutherian Mammals

被引:81
作者
Cheung, Amanda F. P. [1 ]
Kondo, Shinichi [1 ]
Abdel-Mannan, Omar [1 ]
Chodroff, Rebecca A. [1 ]
Sirey, Tamara M. [1 ]
Bluy, Lisa E. [1 ]
Webber, Natalie [1 ]
DeProto, Jamin [1 ]
Karlen, Sarah J. [2 ]
Krubitzer, Leah [2 ]
Stolp, Helen B. [1 ,3 ]
Saunders, Norman R. [3 ]
Molnar, Zoltan [1 ]
机构
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England
[2] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA
[3] Univ Melbourne, Dept Pharmacol, Parkville, Vic 3010, Australia
基金
英国生物技术与生命科学研究理事会; 美国国家科学基金会; 英国医学研究理事会;
关键词
basal progenitors; cortical neurogenesis; cortical unit column; evolutionary biology of cerebral cortex; intermediate progenitors; Monodelphis domestica; INTERMEDIATE PROGENITOR CELLS; WALLABY MACROPUS-EUGENII; SHORT-TAILED OPOSSUM; CEREBRAL-CORTEX; CORTICAL DEVELOPMENT; MONODELPHIS-DOMESTICA; ACCESSIBLE MODEL; CYCLE CONTROL; RADIAL GLIA; EVOLUTION;
D O I
10.1093/cercor/bhp168
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The major lineages of mammals (Eutheria, Metatheria, and Monotremata) diverged more than 100 million years ago and have undergone independent changes in the neocortex. We found that adult South American gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii) possess a significantly lower number of cerebral cortical neurons compared with the mouse (Mus musculus). To determine whether the difference is reflected in the development of the cortical germinal zones, the location of progenitor cell divisions was examined in opossum, tammar wallaby, and rat. The basic pattern of the cell divisions was conserved, but the emergence of a distinctive band of dividing cells in the subventricular zone (SVZ) occurred relatively later in the opossum (postnatal day [P14]) and the tammar wallaby (P40) than in rodents. The planes of cell divisions in the ventricular zone (VZ) were similar in all species, with comparable mRNA expression patterns of Brn2, Cux2, NeuroD6, Tbr2, and Pax6 in opossum (P12 and P20) and mouse (embryonic day 15 and P0). In conclusion, the marsupial neurodevelopmental program utilizes an organized SVZ, as indicated by the presence of intermediate (or basal) progenitor cell divisions and gene expression patterns, suggesting that the SVZ emerged prior to the Eutherian-Metatherian split.
引用
收藏
页码:1071 / 1081
页数:11
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