The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

被引：257

作者：

Arnold, Sebastian J. ^{[2
]}

Huang, Guo-Jen ^{[1
]}

Cheung, Amanda F. P. ^{[3
]}

Era, Takumi ^{[4
]}

Nishikawa, Shin-Ichi ^{[4
]}

Bikoff, Elizabeth K. ^{[2
]}

Molnar, Zoltan ^{[3
]}

Robertson, Elizabeth J. ^{[2
]}

Groszer, Matthias ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[3] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[4] Riken Ctr Dev Biol, Lab Stem Cell Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 18期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

eomesodermin; Tbr2; neuronal progenitor cells; SVZ; brain size;

D O I：

10.1101/gad.475408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.

引用

页码：2479 / 2484

页数：6

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