Melatonin formation in mammals: In vivo perspectives

被引:71
作者
Chattoraj, Asamanja [1 ]
Liu, Tiecheng [1 ]
Zhang, Liang Samantha [2 ]
Huang, Zheping [1 ]
Borjigin, Jimo [1 ,2 ]
机构
[1] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Grad Program Neurosci, Ann Arbor, MI 48109 USA
关键词
Melatonin; Serotonin (5-HT); Pineal gland; Microdialysis; SEROTONIN N-ACETYLTRANSFERASE; SYRIAN-HAMSTER; PINEAL-GLAND; RAT; PROTEIN; STABILITY; EVOLUTION; RHYTHM; LIGHT;
D O I
10.1007/s11154-009-9125-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Melatonin is a hormone secreted from the pineal gland specifically at night and contributes to a wide array of physiological functions in mammals. Melatonin is one of the most well understood output of the circadian clock located in the suprachiasmatic nucleus. Melatonin synthesis is controlled distally via the circadian clock located in the suprachiasmatic nucleus and proximally regulated by norepinephrine released in response to the circadian clock signals. To understand melatonin synthesis in vivo, we have performed microdialysis analysis of the pineal gland, which monitors melatonin as well as the precursor (serotonin) and intermediate (N-acetylserotonin) of melatonin synthesis in freely moving animals in realtime at high resolution. Our data revealed a number of novel features of melatonin production undetected using conventional techniques, which include (1) large inter-individual variations of melatonin onset timing; (2) circadian regulation of serotonin synthesis and secretion in the pineal gland; and (3) a revised view on the rate-limiting step of melatonin formation in vivo. This article will summarize the main findings from our laboratory regarding melatonin formation in mammals.
引用
收藏
页码:237 / 243
页数:7
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