The olefinic aldol reaction. Intramolecular cyclization forming five- and six-membered rings

被引：30

作者：

Nakamura, E ^{[1
]}

Sakata, G ^{[1
]}

Kubota, K ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 115, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00145-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enolate anion undergoes intramolecular addition to a neighboring olefinic bond suitable for cyclization, when the countercation of the enolate is a BuZn(II) cation. Thus, zinc enolates of olefinic N,N-dimethylhydrazone and lactam undergo a 5-exo and 6-exo trigonal cyclization reaction in good to high yield to afford 1,2-substituted cyclopentane and cyclohexane derivatives bearing a hydrazone or lactam side chain. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2157 / 2158

页数：2

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