Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

被引：184

作者：

Blum, R ^{[1
]}

Konnerth, A ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol, Munich, Germany

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00042.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.

引用

收藏

页码：70 / 78

页数：9

相关论文

共 75 条

[1] Kinetics of trkA tyrosine kinase activity and inhibition by K-252a [J].

Angeles, TS ;

Yang, SX ;

Steffler, C ;

Dionne, CA .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 349 (02) :267-274

[2]

Balkowiec A, 2002, J NEUROSCI, V22, P10399

[3] Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway [J].

Baranes, D ;

Lederfein, D ;

Huang, YY ;

Chen, M ;

Bailey, CH ;

Kandel, ER .

NEURON, 1998, 21 (04) :813-825

[4] THE TRK FAMILY OF NEUROTROPHIN RECEPTORS [J].

BARBACID, M .

JOURNAL OF NEUROBIOLOGY, 1994, 25 (11) :1386-1403

[5] The concept of long term potentiation of transmission at synapses [J].

Bennett, MR .

PROGRESS IN NEUROBIOLOGY, 2000, 60 (02) :109-137

[6] Neurobiology - Exciting neurotrophins [J].

Berninger, B ;

Poo, MM .

NATURE, 1999, 401 (6756) :862-863

[7] A neuron-glia signalling network in the active brain [J].

Bezzi, P ;

Volterra, A .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :387-394

[8] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[9] Localization of cellular storage compartments and sites of constitutive and activity-dependent release of nerve growth factor (NGF) in primary cultures of hippocampal neurons [J].

Blochl, A ;

Thoenen, H .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1996, 7 (03) :173-190

[10] Neurotrophin-evoked depolarization requires the sodium channel NaV1.9 [J].

Blum, R ;

Kafitz, KW ;

Konnerth, A .

NATURE, 2002, 419 (6908) :687-693

← 1 2 3 4 5 6 7 8 →