Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

被引：184

作者：

Blum, R ^{[1
]}

Konnerth, A ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol, Munich, Germany

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00042.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.

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页码：70 / 78

页数：9

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