Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I.: Taxonomy, fermentation, isolation and biological activities

被引：62

作者：

Schimana, J

Fiedler, HP

Groth, I

Süssmuth, R

Beil, W

Walker, M

Zeeck, A

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Hans Knoll Inst Naturstoff Forsch EV, D-07745 Jena, Germany

[3] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[4] Med Hsch Hannover, Inst Pharmakol, D-30625 Hannover, Germany

[5] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 08期

关键词：

D O I：

10.7164/antibiotics.53.779

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

引用

页码：779 / 787

页数：9