Inhibitors of HCVNS5B polymerase: Synthesis and structureactivity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives

被引：29

作者：

Krueger, A. Chris ^{[1
]}

Madigan, Darold L. ^{[1
]}

Green, Brian E. ^{[1
]}

Hutchinson, Douglas K. ^{[1
]}

Jiang, Wen W. ^{[1
]}

Kati, Warren M. ^{[1
]}

Liu, Yaya ^{[1
]}

Maring, Clarence J. ^{[1
]}

Masse, Sherie V. ^{[1
]}

McDaniel, Keith F. ^{[1
]}

Middleton, Tim R. ^{[1
]}

Mo, Hongmei ^{[1
]}

Molla, Akhteruzzaman ^{[1
]}

Montgomery, Debra A. ^{[1
]}

Ng, Teresa I. ^{[1
]}

Kempf, Dale J. ^{[1
]}

机构：

[1] Abbott Labs, Infect Dis Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 08期

关键词：

HCV; NS5B; polymerase; 1-hydroxy-4,4-dialkyl-3-oxo 3,4-dihydronaphthalene benzothiadiazine;

D O I：

10.1016/j.bmcl.2007.01.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2289 / 2292

页数：4