Molecular motors

被引：905

作者：

Schliwa, M ^{[1
]}

Woehlke, G ^{[1
]}

机构：

[1] Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

来源：

NATURE | 2003年 / 422卷 / 6933期

关键词：

D O I：

10.1038/nature01601

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide variety of cargo, power cell locomotion, drive cell division and, when combined in large ensembles, allow organisms to move. Motor defects can lead to severe diseases or may even be lethal. Basic principles of motor design and mechanism have now been derived, and an understanding of their complex cellular roles is emerging.

引用

页码：759 / 765

页数：7

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