Preferential benefit of platelet glycoprotein IIb/IIIa receptor blockade: Specific considerations by device and disease state

被引:20
作者
Kereiakes, DJ
机构
[1] Christ Hosp, Carl & Edyth Lindner Ctr Clin Cardiovasc Res, Cincinnati, OH 45219 USA
[2] Ohio Heart Hlth Ctr, Cincinnati, OH USA
关键词
D O I
10.1016/S0002-9149(98)00198-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Several patient subgroups appear to benefit preferentially from inhibition of platelet glycoprotein (GP) IIb/IIIa receptors, In clinical trials the GP IIb/IIIa blocker abciximab (ReoPro; Lilly) proved both safe and effective in improving outcomes after coronary interventions, Endpoints of death, myocardial infarction (MI), and need for urgent intervention were significantly decreased in a randomized placebo-controlled trial of patients treated with abciximab in conjunction with either low-dose or standard-dose weight-adjusted heparin during elective percutaneous coronary revascularization. In addition, studies have shown that patients undergoing unplanned stent deployment or ablative technologies benefit from GP IIb/IIIa blockade, Patients undergoing saphenous vein graft intervention also derive specific benefits, These agents-specifically abciximab, eptifibatide (INTEGRILIN; Cor/Schering), and tiro-fiban-have also benefited patients with the acute coronary syndromes (e.g., unstable angina) by decreasing ischemic events. (C) 1998 by Excerpta Medica, Inc.
引用
收藏
页码:49E / 54E
页数:6
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