cross-presentation;
cytotoxic T cell;
bacterial immunity;
viral immunity;
radiation chimera;
D O I:
10.1084/jem.192.8.1135
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Bone marrow (BM)-derived antigen-presenting cells (APCs) are potent stimulators of T cell immune responses. We investigated the requirements for antigen presentation by these cells in priming cytotoxic T lymphocyte (CTL) responses to intracellular bacterial and viral pathogens. [Parent-->F-1] radiation BM chimeras were constructed using C57BL/6 donors and (C57BL/6 X BALB/c)F-1 recipients. Infection of chimeric mice with either Listeria monocytogenes or vaccinia virus expressing the nucleoprotein (NP) antigen from lymphocytic choriomeningitis virus (LCMV) primed H2-D-b-restricted, but not H2-K-d-restricted CTL responses, demonstrating the requirement for BM-derived APCs for successful priming of CTL responses to these pathogens. Surprisingly, this did not hold true for chimeric mice infected with LCMV itself. LCMV-infected animals developed strong CTL responses specific for both H2-D-b- and H2-L-d-restricted NP epitopes. These findings indicate that in vivo priming of CTL responses to LCMV is remarkably insensitive to deficiencies in antigen presentation by professional BM-derived APCs.
机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
KOSAKA, H
SURH, CD
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机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
SURH, CD
SPRENT, J
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
KOSAKA, H
SURH, CD
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
SURH, CD
SPRENT, J
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USAScripps Res Inst, RES INST,DEPT IMMUNOL,IMM4A, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA