Radioimmunoscintigraphy with In-111-labeled capromab pendetide predicts prostate cancer response to salvage radiotherapy after failed radical prostatectomy

被引:106
作者
Kahn, D
Williams, RD
Haseman, MK
Reed, NL
Miller, SJ
Gerstbrein, J
机构
[1] Dept Vet Affairs Med Ctr, Nucl Med Serv, Iowa City, IA 52246 USA
[2] Univ Iowa, Coll Med, Iowa City, IA USA
[3] Sutter Gen Hosp, Sacramento, CA USA
关键词
D O I
10.1200/JCO.1998.16.1.284
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: We investigated the ability of In-111-capromab pendetide to separate patients who have failed radical prostatectomy into categories of those who would versus those who would not respond to salvage radiotherapy, Methods: prostate-specific antigen (PSA) levels in 32 men with prostate cancer who had failed radical prostatestomy and had undergone a whole-body In-111-capromab pendetide scan were followed-up for 13 months (median) after salvage radiotherapy to the pelvis, A logistic regression model was used to determine whether the scan findings, as well as other clinical variables, were associated with a durable complete response (DCR), a nondurable response (NDR), or no response (NR). Results: Sixteen of 23 (70%) men with a normal scan outside the prostatic fossa achieved a DCR after salvage radiotherapy versus two of nine (22%) who had a positive scan outside the prostate fossa and pelvis (P = .0225, Fisher's exact test), predicted probability (95% confidence interval [CI]) that a DCR would be obtained with a normal scan was 0.88 (0.55 to 6.98); for men with a positive scan limited to the prostatic fossa it was 0.62 (0.42 to 0.79): and for men with a positive scan outside the pelvis it was 0.27 (0.09 to 0.58), No other variables before radiotherapy showed a significant association with the DCR rate. Conclusion: Salvage radiotherapy is statistically more likely to lead to a durable complete PSA response in men with prostate cancer who have failed radical prostatectomy and have a negative In-111-capromab pendetide scan outside the pelvis as compared with those who have a positive scan. This is a government work. There are no restrictions on its use.
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页码:284 / 289
页数:6
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