Adenosine(5′) oligophospho-(5′) guanosines and guanosine(5′) oligophospho-(5′) guanosines in human platelets

被引：46

作者：

Schlüter, H

Gross, I

Bachmann, J

Kaufmann, R

van der Giet, M

Tepel, M

Nofer, JR

Assmann, G

Karas, M

Jankowski, J

Zidek, W

机构：

[1] Ruhr Univ Bochum, Klin Marienhosp, Med Klin 1, D-44625 Herne, Germany

[2] Univ Dusseldorf, Inst Lasermed, D-40001 Dusseldorf, Germany

[3] Univ Munster, Inst Biochem, D-48149 Munster, Germany

[4] Univ Munster, Inst Klin Chem & Lab Med, D-48129 Munster, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1998年 / 101卷 / 03期

关键词：

dinucleoside polyphosphates; platelets; growth actors; cytosolic free Ca2+ concentration; vascular smooth muscle cells;

D O I：

10.1172/JCI119882

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (Ap(n)G; n = 3-6) as well as diguanosine polyphosphates (Gp(n)G; n = 3-6) in human platelets, For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass spectrometry, and enzymatic cleavage experiments were used. The adenosine(5') oligophospho-(5') guanosines act as vasoconstrictors and growth factors, The diguanosine polyphosphates are potent modulators of growth in vascular smooth muscle cells, but do not affect vascular tone.

引用

页码：682 / 688

页数：7