1,25-dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts

被引：140

作者：

Kim, S ^{[1
]}

Shevde, NK ^{[1
]}

Pike, JW ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期

关键词：

vitamin D receptor; retinoid X receptor; co-activators; cycling; vitamin D antagonist; chromatin immunoprecipitation;

D O I：

10.1359/JBMR.041112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1,25(OH)(2)D-3 induces gene expression through the VDR. We used chromatin immunoprecipitation techniques to explore this 1,25(OH)(2)D-3-induced process on the 25-hydroxyvitamin D-3-24-hydroxylase (Cyp24) and Opn gene promoters in intact osteoblasts. Our studies show that 1,25(OH)(2)D-3-induced transactivation is a dynamic process that involves promoter-specific localization of VDR and RXR, recruitment of histone acetyltransferase complexes, and in the case of the Cyp24 gene, modification of histone 4.

引用

收藏

页码：305 / 317

页数：13

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