Regulators of apoptosis as anticancer targets

被引：10

作者：

Tolcher, AW

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78229 USA

[2] Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2002年 / 16卷 / 05期

关键词：

D O I：

10.1016/S0889-8588(02)00046-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several therapeutic strategies for drug development focus on the enhancement of tumor cell apoptosis secondary to chemotherapy, irradiation, and hormone-therapy, and improved therapeutic gain for patients. Rationally derived molecularly-targeted agents directed to the regulation of bcl-2 family members (intrinsic pathway) are in late clinical studies, whereas several strategies that target the tumor necrosis factor receptor family (extrinsic pathway of apoptosis) are in late preclinical development. These therapeutic agents and the pathways that are targeted. are reviewed.

引用

页码：1255 / +

页数：15

共 95 条

[11] Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease [J].