A general protocol for the regio high yielding opening of different glycidol derivatives

被引：50

作者：

Bonini, C

Chiummiento, L

Lopardo, MT

Pullez, M

Colobert, F

Solladié, G

机构：

[1] Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy

[2] Univ Strasbourg 1, ECPM, CNRS, Lab Stereochim, F-67087 Strasbourg 2, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 13期

关键词：

glycidol; vinylmagnesium bromide; cuprate; ring opening;

D O I：

10.1016/S0040-4039(03)00372-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Differently protected glycidol derivatives (with Bn, TBDPS, TBS and MPM groups) have been tested for regioselective ring opening with vinylmagnesium bromide in order to obtain useful five-carbon functionalised homoallylic alcohols. Careful choice of the reagents and experimental conditions allowed a general access to important chiral synthons for asymmetric synthesis. (C) 2003 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2695 / 2697

页数：3

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