Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

被引:123
作者
Koevesdi, Erzsebet [1 ]
Lueckl, Janos [2 ]
Bukovics, Peter [1 ,3 ]
Farkas, Orsolya [1 ]
Pal, Jozsef [1 ]
Czeiter, Endre [1 ]
Szellar, Dora [1 ]
Doczi, Tamas [1 ]
Komoly, Samuel [4 ]
Bueki, Andras [1 ]
机构
[1] Univ Pecs, Dept Neurosurg, H-7623 Pecs, Hungary
[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[3] Hungarian Acad Sci, Neurobiol Res Grp, Pecs, Hungary
[4] Univ Pecs, Dept Neurol, H-7623 Pecs, Hungary
关键词
Review; Mild; Severe; Pediatric; Traumatic brain injury; Biomarkers; Outcome; NEURON-SPECIFIC-ENOLASE; SERUM S-100B PROTEIN; CORTICAL IMPACT INJURY; SEVERE HEAD-INJURY; SPECTRIN BREAKDOWN PRODUCTS; FLUID APOLIPOPROTEIN-E; AMYLOID-BETA-PROTEIN; FIBRILLARY ACIDIC PROTEIN; GLASGOW COMA SCALE; ALPHA-II-SPECTRIN;
D O I
10.1007/s00701-009-0463-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This review summarizes protein biomarkers in mild and severe traumatic brain injury in adults and children and presents a strategy for conducting rationally designed clinical studies on biomarkers in head trauma. We performed an electronic search of the National Library of Medicine's MEDLINE and Biomedical Library of University of Pennsylvania database in March 2008 using a search heading of traumatic head injury and protein biomarkers. The search was focused especially on protein degradation products (spectrin breakdown product, c-tau, amyloid-beta(1-42)) in the last 10 years, but recent data on "classical" markers (S-100B, neuron-specific enolase, etc.) were also examined. We identified 85 articles focusing on clinical use of biomarkers; 58 articles were prospective cohort studies with injury and/or outcome assessment. We conclude that only S-100B in severe traumatic brain injury has consistently demonstrated the ability to predict injury and outcome in adults. The number of studies with protein degradation products is insufficient especially in the pediatric care. Cohort studies with well-defined end points and further neuroproteomic search for biomarkers in mild injury should be triggered. After critically reviewing the study designs, we found that large homogenous patient populations, consistent injury, and outcome measures prospectively determined cutoff values, and a combined use of different predictors should be considered in future studies.
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页码:1 / 17
页数:17
相关论文
共 181 条
[61]   MULTIPLE ISOFORMS OF HUMAN MICROTUBULE-ASSOCIATED PROTEIN-TAU - SEQUENCES AND LOCALIZATION IN NEUROFIBRILLARY TANGLES OF ALZHEIMERS-DISEASE [J].
GOEDERT, M ;
SPILLANTINI, MG ;
JAKES, R ;
RUTHERFORD, D ;
CROWTHER, RA .
NEURON, 1989, 3 (04) :519-526
[62]   BRAIN SPECTRIN - OF MICE AND MEN [J].
GOODMAN, SR ;
ZIMMER, WE ;
CLARK, MB ;
ZAGON, IS ;
BARKER, JE ;
BLOOM, ML .
BRAIN RESEARCH BULLETIN, 1995, 36 (06) :593-606
[63]   Survival and functional outcome in pediatric traumatic brain injury: A retrospective review and analysis of predictive factors [J].
Hackbarth, RM ;
Rzeszutko, KM ;
Sturm, G ;
Donders, J ;
Kuldanek, AS ;
Sanfilippo, DJ .
CRITICAL CARE MEDICINE, 2002, 30 (07) :1630-1635
[64]   S-100 PROTEIN AND NEURON-SPECIFIC ENOLASE IN CSF AFTER EXPERIMENTAL TRAUMATIC OR FOCAL ISCHEMIC BRAIN-DAMAGE [J].
HARDEMARK, HG ;
ERICSSON, N ;
KOTWICA, Z ;
RUNDSTROM, G ;
MENDELHARTVIG, I ;
OLSSON, Y ;
PAHLMAN, S ;
PERSSON, L .
JOURNAL OF NEUROSURGERY, 1989, 71 (05) :727-731
[65]  
HARRIS AS, 1988, J BIOL CHEM, V263, P15754
[66]   Outcome after severe non-accidental head injury [J].
Haviland, J ;
Russell, RIR .
ARCHIVES OF DISEASE IN CHILDHOOD, 1997, 77 (06) :504-507
[67]   Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury [J].
Hayakata, T ;
Shiozaki, T ;
Tasaki, O ;
Ikegawa, H ;
Inoue, Y ;
Toshiyuki, F ;
Hosotubo, H ;
Kieko, F ;
Yamashita, T ;
Tanaka, H ;
Shimazu, T ;
Sugimoto, H .
SHOCK, 2004, 22 (02) :102-107
[68]   Release of glial tissue-specific proteins after acute stroke - A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein [J].
Herrmann, M ;
Vos, P ;
Wunderlich, MT ;
de Bruijn, CHMM ;
Lamers, KJB .
STROKE, 2000, 31 (11) :2670-2677
[69]  
Herrmann M, 1999, RESTOR NEUROL NEUROS, V14, P109
[70]   Cerebrospinal fluid aβ42 is reduced in multiple system atrophy but normal in Parkinson's disease and progressive supranuclear palsy [J].
Holmberg, B ;
Johnels, B ;
Blennow, K ;
Rosengren, L .
MOVEMENT DISORDERS, 2003, 18 (02) :186-190