Uracil- and thymine-substituted thymidine and uridine derivatives

被引：20

作者：

Costa, AM ^{[1
]}

Faja, M ^{[1
]}

Farràs, J ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(98)00100-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four possible 3'-uracil-1-yl and 3'-thymin-1-yl derivatives of 3'-deoxythymidine and the four analogous derivatives of 2'-deoxyuridine have been synthesised from thymidine and uridine, respectively. Advantages of the 2-(methoxycarbonyl)vinyl group to prevent the formation of anhydronucleosides and of SnCl2/PhSH/Et3N in relation to H-2/Pd for the reduction of most azido groups are disclosed. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1835 / 1838

页数：4

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