REACTION OF URIDINES AND THYMIDINES WITH METHYL PROPYNOATE - A NEW N-3 PROTECTING GROUP

被引：21

作者：

FAJA, M ^{[1
]}

ARIZA, X ^{[1
]}

GALVEZ, C ^{[1
]}

VILARRASA, J ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC QUIM,DEPT QUIM ORGAN,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 18期

关键词：

D O I：

10.1016/0040-4039(95)00460-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast conjugated addition takes place when uridines and thymidines are treated with HC-C-COOMe in the presence of suitable bases such as DMAP. As the resulting N-CH=CH-COOMe moiety appears to be very stable under acidic conditions, but it is readily cleaved by nucleophiles such as pyrrolidine or methylamine, a new protection protocol for N-3 of uridines and thymidines is disclosed.

引用

页码：3261 / 3264

页数：4

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