Bilateral thalamic gray matter changes in patients with restless legs syndrome

被引:92
作者
Etgen, T
Draganski, B
Llg, C
Schröder, M
Geisler, P
Hajak, G
Eisensehr, L
Sander, D
May, A
机构
[1] Tech Univ Munich, Dept Neurol, D-8000 Munich, Germany
[2] Univ Regensburg, Dept Neurol, D-8400 Regensburg, Germany
[3] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-8000 Munich, Germany
[4] Univ Regensburg, Dept Psychiat & Psychotherapy, D-8400 Regensburg, Germany
[5] Univ Munich, Dept Neurol, D-80539 Munich, Germany
关键词
restless legs; voxel based morphometry; MRI; thalamus; pulvinar;
D O I
10.1016/j.neuroimage.2004.10.021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Restless legs syndrome (RLS) is a common neurological disorder of a primary unpleasant sensation with an urge to move the legs occurring at rest. The etiology of idiopathic RLS is unknown and structural cerebral abnormalities have so far not been detected. We studied 51 right-handed patients with an idiopathic restless legs syndrome in two independent samples (Regensburg RLS-group: n = 28, Munich RLS-group: n = 23) and compared them to 51 sex- and age-matched healthy volunteers. High-resolution T1-weighted magnetic resonance imaging (MRI) of each subject was obtained and analyzed using voxel-based morphometry (VBM) to detect regionally specific differences in gray matter between patients and controls. Conjunction analysis was used to combine results from both centers. In patients with idiopathic RLS, both study centers observed independently a bilateral gray matter increase in the pulvinar. In the conjunction analysis including all patients and controls from both study centers, a significant gray matter increase in the pulvinar bilaterally (right: x = 16, y = -21, z = 12, Z = 4.57, left: x = -16, y = -24, z = 12, Z = 4.10) was present. This is the first demonstration of structural changes in the brain of patients with idiopathic RLS. These changes in thalamic structures are either involved in the pathogenesis of RLS or may reflect a consequence of chronic increase in afferent input of behaviorally relevant information. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1242 / 1247
页数:6
相关论文
共 57 条
[31]   IDENTIFICATION OF EXTRASTRIATAL DOPAMINE D2 RECEPTORS IN POSTMORTEM HUMAN BRAIN WITH [I-125] EPIDEPRIDE [J].
KESSLER, RM ;
WHETSELL, WO ;
ANSARI, MS ;
VOTAW, JR ;
DEPAULIS, T ;
CLANTON, JA ;
SCHMIDT, DE ;
MASON, NS ;
MANNING, RG .
BRAIN RESEARCH, 1993, 609 (1-2) :237-243
[32]   Voxel-based morphornetric analysis of gray matter in first episode schizophrenia [J].
Kubicki, M ;
Shenton, ME ;
Salisbury, DF ;
Hirayasu, Y ;
Kasai, K ;
Kikinis, R ;
Jolesz, FA ;
McCarley, RW .
NEUROIMAGE, 2002, 17 (04) :1711-1719
[33]  
Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO
[34]  
2-8
[35]   Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder [J].
Littner, MR ;
Kushida, C ;
Anderson, WM ;
Bailey, D ;
Berry, RB ;
Hirshkowitz, M ;
Kapen, S ;
Kramer, M ;
Lee-Chiong, T ;
Li, KK ;
Loube, DL ;
Morgenthaler, T ;
Wise, M .
SLEEP, 2004, 27 (03) :557-559
[36]   Navigation-related structural change in the hippocampi of taxi drivers [J].
Maguire, EA ;
Gadian, DG ;
Johnsrude, IS ;
Good, CD ;
Ashburner, J ;
Frackowiak, RSJ ;
Frith, CD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4398-4403
[37]   Correlation between structural and functional changes in brain in an idiopathic headache syndrome [J].
May, A ;
Ashburner, J ;
Büchel, C ;
McGonigle, DJ ;
Friston, KJ ;
Frackowiak, RSJ ;
Goadsby, PJ .
NATURE MEDICINE, 1999, 5 (07) :836-838
[38]  
McCormick David A., 1994, Current Opinion in Neurobiology, V4, P550, DOI 10.1016/0959-4388(94)90056-6
[39]  
Mummery CJ, 2000, ANN NEUROL, V47, P36
[40]   PET mapping of extrastriatal D2-like dopamine receptors in the human brain using an anatomic standardization technique and [11C]FLB 457 [J].
Okubo, Y ;
Olsson, H ;
Ito, H ;
Lofti, M ;
Suhara, T ;
Halldin, C ;
Farde, L .
NEUROIMAGE, 1999, 10 (06) :666-674