Long-term progression in chronic manganism - Ten years of follow-up

被引：127

作者：

Huang, CC

Chu, NS

Lu, CS

Chen, RS

Calne, DB

机构：

[1] Chang Gung Mem Hosp & Med Coll, Dept Neurol, Taipei, Taiwan

[2] Univ British Columbia, Ctr Neurodegenerat Disorders, Div Neurol, Vancouver, BC V5Z 1M9, Canada

来源：

NEUROLOGY | 1998年 / 50卷 / 03期

关键词：

D O I：

10.1212/WNL.50.3.698

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 +/- 4.2 in 1987 to 28.3 +/- 6.70 in 1991 and then to 38.1 +/- 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.

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收藏

页码：698 / 700

页数：3

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