RTEL-1 Enforces Meiotic Crossover Interference and Homeostasis

被引：136

作者：

Youds, Jillian L. ^{[1
]}

Mets, David G. ^{[2
]}

McIlwraith, Michael J. ^{[3
]}

Martin, Julie S. ^{[1
]}

Ward, Jordan D. ^{[1
]}

ONeil, Nigel J. ^{[4
]}

Rose, Ann M. ^{[4
]}

West, Stephen C. ^{[3
]}

Meyer, Barbara J. ^{[2
]}

Boulton, Simon J. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England

[2] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Canc Res UK, London Res Inst, Genet Recombinat Lab, S Mimms EN6 3LD, Herts, England

[4] Univ British Columbia, Fac Med, Dept Med Genet, Vancouver, BC V6T 1Z4, Canada

来源：

SCIENCE | 2010年 / 327卷 / 5970期

关键词：

CAENORHABDITIS-ELEGANS; STRAND-EXCHANGE; C-ELEGANS; RECOMBINATION; CHROMOSOME; PROTEINS; YEAST;

D O I：

10.1126/science.1183112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meiotic crossovers (COs) are tightly regulated to ensure that COs on the same chromosome are distributed far apart ( crossover interference, COI) and that at least one CO is formed per homolog pair (CO homeostasis). CO formation is controlled in part during meiotic double-strand break (DSB) creation in Caenorhabditis elegans, but a second level of control must also exist because meiotic DSBs outnumber COs. We show that the anti-recombinase RTEL-1 is required to prevent excess meiotic COs, probably by promoting meiotic synthesis-dependent strand annealing. Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers.

引用

页码：1254 / 1258

页数：5

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