Id proteins -: Tumor markers or oncogenes?

被引：50

作者：

Hasskarl, J

Münger, K

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Harvard Ctr Canc Biol, Boston, MA 02115 USA

来源：

CANCER BIOLOGY & THERAPY | 2002年 / 1卷 / 02期

关键词：

basic helix-loop-helix proteins; transcription factor; cell cycle; differentiation; tumorigenesis; oncogenes; Id proteins;

D O I：

10.4161/cbt.50

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins act as dominant negative inhibitors of differentiation-specific basic Helix-Loop-Helix (bHLH) transcription factors. Id proteins negatively regulate cellular differentiation and they induce proliferation by modulating different cell cycle regulators both by direct and indirect mechanisms. Ectopic expression of Id proteins in tissue culture models can result in cellular immortalization and abrogation of differentiation processes. Recent reports show that Id proteins are overexpressed in various cancer types implying a role of these regulatory proteins in carcinogenesis. This review focuses on the biology of the Id proteins and their role as potential oncogenes.

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收藏

页码：91 / 96

页数：6

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