Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae

被引：36

作者：

Chen, A ^{[1
]}

Boulton, IC ^{[1
]}

Pongoski, J ^{[1
]}

Cochrane, A ^{[1
]}

Gray-Owen, SD ^{[1
]}

机构：

[1] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON, Canada

来源：

AIDS | 2003年 / 17卷 / 04期

关键词：

D O I：

10.1097/00002030-200303070-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gonorrhoea enhances the transmission of HIV through increased viral shedding and the increased probability of seroconversion among previously HIV-negative individuals. However, the mechanism(s) underlying these influences remain poorly understood. We demonstrated that exposure to Neisseria gonorrhoeae induces the nuclear factor kappa B-dependent transcription from the HIV-1 long terminal repeat in derivatives of the jurkat CD4 T cell line. These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression.

引用

页码：625 / 628

页数：4

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