In situ formation and reaction of 2-pyridylboronic esters

被引：42

作者：

Fuller, AA ^{[1
]}

Hester, HR ^{[1
]}

Salo, EV ^{[1
]}

Stevens, EP ^{[1
]}

机构：

[1] Davidson Coll, Dept Chem, Davidson, NC 28036 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(03)00419-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Pyridylboronic esters were generated by cross-coupling 2-bromopyridines with bis(pinacolato)diboron in the presence of a base and palladium catalyst. The boronic esters reacted in situ with unreacted 2-bromopyridines to afford high yields of 2,2'-bipyridines as homocoupled products. Depending upon the reaction conditions, varying amounts of protodeboronated products were also observed. An attempted cross-coupling between two different 2-bromopyridines produced a nearly statistical mixture of homo- and cross-coupled products. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：2935 / 2938

页数：4

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