Food intake in rhesus monkeys following central administration of orexins

被引：13

作者：

Ramsey, JJ ^{[1
]}

Kemnitz, JW

Newton, W

Hagopian, K

Patterson, TA

Swick, AG

机构：

[1] Univ Calif Davis, Sch Vet Med, Dept Mol Sci, Davis, CA 95616 USA

[2] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA

[3] Pfizer Global Res & Dev, Dept Metab Dis, Groton, CT 06340 USA

来源：

REGULATORY PEPTIDES | 2005年 / 124卷 / 1-3期

关键词：

orexin A; orexin B; neuropeptide Y; obesity;

D O I：

10.1016/j.regpep.2004.07.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 mug) or orexin B (10, 30, or 100 mug). When compared to vehicle injections, the 10 and 20 mug doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 mug orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：209 / 214

页数：6

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