The G protein-coupled receptor repertoires of human and mouse

被引：563

作者：

Vassilatis, DK ^{[1
]}

Hohmann, JG ^{[1
]}

Zeng, H ^{[1
]}

Li, FS ^{[1
]}

Ranchalis, JE ^{[1
]}

Mortrud, MT ^{[1
]}

Brown, A ^{[1
]}

Rodriguez, SS ^{[1
]}

Weller, JR ^{[1
]}

Wright, AC ^{[1
]}

Bergmann, JE ^{[1
]}

Gaitanaris, GA ^{[1
]}

机构：

[1] Primal Inc, Seattle, WA 98104 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 08期

关键词：

D O I：

10.1073/pnas.0230374100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diverse members of the G protein-coupled receptor (GPCR) superfamily participate in a variety of physiological functions and are major targets of pharmaceutical drugs. Here we report that the repertoire of GPCRs for endogenous ligands consists of 367 receptors in humans and 392 in mice. Included here are 26 human and 83 mouse GPCRs not previously identified. A direct comparison of GPCRs in the two species reveals an unexpected level of orthology. The evolutionary preservation of these molecules argues against functional redundancy among highly related receptors. Phylogenetic analyses cluster 60% of GPCRs according to ligand preference, allowing prediction of ligand types for dozens of orphan receptors. Expression profiling of 100 GPCRs demonstrates that most are expressed in multiple tissues and that individual tissues express multiple GPCRs. Over 90% of GPCRs are expressed in the brain. Strikingly, however, the profiles of most GPCRs are unique, yielding thousands of tissue- and cell-specific receptor combinations for the modulation of physiological processes.

引用

页码：4903 / 4908

页数：6

共 35 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] Molecular tinkering of G protein-coupled receptors: an evolutionary success [J].