Control of osteoblast function and regulation of bone mass

被引：1089

作者：

Harada, S ^{[1
]}

Rodan, GA ^{[1
]}

机构：

[1] Merck Res Labs, Dept Bone Biol & Osteoporosis Res, W Point, PA 19002 USA

来源：

NATURE | 2003年 / 423卷 / 6937期

关键词：

D O I：

10.1038/nature01660

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

引用

页码：349 / 355

页数：7

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