Stem Cells in the Treatment of Heart Disease

被引:40
作者
Janssens, Stefan [1 ,2 ]
机构
[1] Univ Louvain, VIB, Univ Hosp Gasthuisberg, Div Cardiol, B-3000 Louvain, Belgium
[2] Univ Louvain, VIB, Univ Hosp Gasthuisberg, Vesalius Res Ctr, B-3000 Louvain, Belgium
来源
ANNUAL REVIEW OF MEDICINE | 2010年 / 61卷
关键词
cardiac stem cells; neovascularization; cardiomyogenesis; regenerative medicine (myocardial repair); transdifferentiation; ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; CARDIAC PROGENITOR CELLS; REPAIR-AMI TRIAL; MONONUCLEAR-CELLS; TRANSCORONARY TRANSPLANTATION; INTRACORONARY TRANSPLANTATION; HEBE TRIAL; THERAPY;
D O I
10.1146/annurev.med.051508.215152
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Progenitor cells residing in bone marrow, adipose tissue, and skeletal Muscle or circulating in the blood are capable of improving myocardial function in preclinical models. hi contrast, early clinical studies using bone marrow cells have shown mixed results and reflect our incomplete understanding of underlying mechanisms. Recent identification of various cardiac precursor cells has suggested an endogenous reservoir for cell-based repair. However, confronted with massive cardiac cell loss, inventive strategies and enabling technologies are required to mobilize or deliver functionally competent progenitor cells to sites of injury or to effectively stimulate endogenous repair. We review our present knowledge in this promising and rapidly evolving development in cardiovascular medicine and highlight obstacles as well as opportunities.
引用
收藏
页码:287 / 300
页数:14
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