Lipid Rafts As a Membrane-Organizing Principle

被引:3377
作者
Lingwood, Daniel [1 ]
Simons, Kai [1 ]
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
关键词
GPI-ANCHORED PROTEINS; PLASMA-MEMBRANE; CELL-MEMBRANES; DETERGENT RESISTANCE; BILAYER THICKNESS; PHASE-SEPARATION; CROSS-LINKING; CHOLESTEROL; VESICLES; MODEL;
D O I
10.1126/science.1174621
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally segregate its constituents. This capability is based on dynamic liquid-liquid immiscibility and underlies the raft concept of membrane subcompartmentalization. Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and trafficking. Here we review the evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity.
引用
收藏
页码:46 / 50
页数:5
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