Prozac: Panacea or puzzle?

被引：78

作者：

Stanford, SC

机构：

[1] Department of Pharmacology, University College London, London WC1E6BT, Gower Street

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1996年 / 17卷 / 04期

关键词：

D O I：

10.1016/0165-6147(96)81591-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Selective 5-HT (serotonin) reuptake inhibitors (SSRIs) lack many of the adverse side-effects of older antidepressants. One of these compounds, fluoxetine (Prozac), has acquired manifest public awareness that is not evident with other SSRIs. Here, Clare Stanford compares the basic pharmacology of SSRIs to determine whether fluoxetine has any atypical features, and thus provide scientific justification for the attention focused on this compound. Ironically, fluoxetine might be distinctive in that it is the least selective SSRI and has marked effects on catecholamine function in the brain.

引用

收藏

页码：150 / 154

页数：5

相关论文

共 48 条

[31] EFFECTS OF ANTI-DEPRESSANTS ON SEROTONIN TURNOVER IN DISCRETE REGIONS OF RAT-BRAIN [J].

MARCO, EJ ;

MEEK, JL .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1979, 306 (01) :75-79

[32]

MATSUMOTO M, 1995, J PHARMACOL EXP THER, V272, P1044

[33] EFFECT OF LONG-TERM ADMINISTRATION OF ANTIDEPRESSANT DRUGS ON THE 5-HT3 RECEPTORS THAT ENHANCE THE ELECTRICALLY-EVOKED RELEASE OF [H-3] NORADRENALINE IN THE RAT HIPPOCAMPUS [J].

MONGEAU, R ;

DEMONTIGNY, C ;

BLIER, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 271 (01) :121-129

[34] EDITORIAL - VENLAFAXINE - THE YIN AND YANG OF ANTIDEPRESSANTS [J].

NUTT, DJ .

JOURNAL OF PSYCHOPHARMACOLOGY, 1995, 9 (03) :205-206

[35] EFFECTS OF 21 DAYS TREATMENT WITH FLUOXETINE ON STIMULATED ENDOGENOUS 5-HYDROXYTRYPTAMINE OVERFLOW IN THE RAT DORSAL RAPHE AND SUPRACHIASMATIC NUCLEUS STUDIED USING FAST CYCLIC VOLTAMMETRY IN-VITRO [J].

OCONNOR, JJ ;

KRUK, ZL .

BRAIN RESEARCH, 1994, 640 (1-2) :328-335

[36] CHANGES IN EXTRACELLULAR PVN MONOAMINES AND MACRONUTRIENT INTAKE AFTER IDAZOXAN OR FLUOXETINE INJECTION [J].

PAEZ, X ;

LEIBOWITZ, SF .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 46 (04) :933-941

[37] EFFECT OF FLUOXETINE ON SEROTONIN AND DOPAMINE CONCENTRATION IN MICRODIALYSIS FLUID FROM RAT STRIATUM [J].

PERRY, KW ;

FULLER, RW .

LIFE SCIENCES, 1992, 50 (22) :1683-1690

[38]

RICHELSON E, 1984, J PHARMACOL EXP THER, V230, P94

[39] BLOCKADE BY ANTIDEPRESSANTS AND RELATED-COMPOUNDS OF BIOGENIC-AMINE UPTAKE INTO RAT-BRAIN SYNAPTOSOMES - MOST ANTIDEPRESSANTS SELECTIVELY BLOCK NOREPINEPHRINE UPTAKE [J].

RICHELSON, E ;

PFENNING, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 104 (3-4) :277-286

[40] INCREASE IN EXTRACELLULAR SEROTONIN PRODUCED BY UPTAKE INHIBITORS IS ENHANCED AFTER CHRONIC TREATMENT WITH FLUOXETINE [J].

RUTTER, JJ ;

GUNDLAH, C ;

AUERBACH, SB .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :183-186

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