Clinical comparison of anti-MuSK- vs anti-AChR-positive and seronegative myasthenia gravis

被引：125

作者：

Deymeer, F. ^{[1
]}

Gungor-Tuncer, O.

Yilmaz, V.

Parman, Y.

Serdaroglu, P.

Ozdemir, C.

Vincent, A.

Saruhan-Direskeneli, G.

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34390 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34390 Istanbul, Turkey

[3] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Neurosci Grp, Oxford OX3 9DU, England

来源：

NEUROLOGY | 2007年 / 68卷 / 08期

关键词：

D O I：

10.1212/01.wnl.0000254620.45529.97

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared 65 anti-acetylcholine receptor (AChR)-negative myasthenia gravis (MG) patients, including 32 anti-muscle-specific tyrosine kinase (MuSK)-positive (49%) and 33 anti-MuSK-negative (seronegative) (51%) patients, with 161 anti-AChR-positive MG patients. The anti-MuSK-positive group had a higher frequency of bulbar involvement and respiratory crises. The seronegative group was in between the anti-MuSK positive and the anti-AChR positive groups, being closer to the latter, with regard to the severity of the disease. At the end of follow-up, the outcome of the anti-MuSK-positive patients was not different from that of the anti-AChR-positive patients, although their maintenance corticosteroid dose was higher. The seronegative patients had better outcome than the other two groups.

引用

页码：609 / 611

页数：3

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