Microarrays: new tools for transplantation research

被引：16

作者：

Chua, MS ^{[1
]}

Sarwal, MM ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

来源：

PEDIATRIC NEPHROLOGY | 2003年 / 18卷 / 04期

关键词：

microarray; gene expression; renal transplantation; acute rejection;

D O I：

10.1007/s00467-003-1083-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The advent of DNA microarray technology has greatly enhanced our potential to understand the molecular basis of human diseases and to aid in more accurate classification, diagnosis and/or prognosis. This powerful, flexible and highly informative technique has been adopted by many biomedical research disciplines. The use of DNA microarrays for gene expression profiling of patients undergoing organ transplantation has diagnostic and therapeutic potential. By generating global views of the gene expression changes in renal graft function post transplantation, DNA microarray technology will provide important information to improve our understanding of the molecular basis of various causes of graft dysfunction, and therefore suggest improved diagnosis, disease classification, and treatment.

引用

页码：319 / 327

页数：9

共 41 条

[1] Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology [J].

Akalin, E ;

Hendrix, RC ;

Polavarapu, RG ;

Pearson, TC ;

Neylan, JF ;

Larsen, CP ;

Lakkis, FG .

TRANSPLANTATION, 2001, 72 (05) :948-953

[2] Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis [J].

Alevizos, I ;

Mahadevappa, M ;

Zhang, X ;

Ohyama, H ;

Kohno, Y ;

Posner, M ;

Gallagher, GT ;

Varvares, M ;

Cohen, D ;

Kim, D ;

Kent, R ;

Donoff, RB ;

Todd, R ;

Yung, CM ;

Warrington, JA ;

Wong, DTW .

ONCOGENE, 2001, 20 (43) :6196-6204

[3] Towards a novel classification of human malignancies based on gene expression patterns [J].

Alizadeh, AA ;

Ross, DT ;

Perou, CM ;

van de Rijn, M .

JOURNAL OF PATHOLOGY, 2001, 195 (01) :41-52

[4] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[5] Singular value decomposition for genome-wide expression data processing and modeling [J].

Alter, O ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10101-10106

[6]

Bard JBL, 1999, INT J DEV BIOL, V43, P397

[7] Development of a toxicological gene array and quantitative assessment of this technology [J].

Bartosiewicz, M ;

Trounstine, M ;

Barker, D ;

Johnston, R ;

Buckpitt, A .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 376 (01) :66-73

[8] Knowledge-based analysis of microarray gene expression data by using support vector machines [J].

Brown, MPS ;

Grundy, WN ;

Lin, D ;

Cristianini, N ;

Sugnet, CW ;

Furey, TS ;

Ares, M ;

Haussler, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) :262-267

[9] Exploring the new world of the genome with DNA microarrays [J].

Brown, PO ;

Botstein, D .

NATURE GENETICS, 1999, 21 (Suppl 1) :33-37

[10]

CHAN V, GENE EXPRESSION

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