Use of antibodies to dissect the components of a catalytic event. The cyclopropenone hapten

被引：3

作者：

Grynszpan, F

Keinan, E

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 08期

关键词：

D O I：

10.1039/a800274f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antibodies elicited against the planar cyclopropenone hapten I efficiently catalyze ester hydrolysis, highlighting the importance of charge rather than shape complementarity as a design element of hydrolytic antibodies.

引用

页码：865 / 866

页数：2

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